Aktivitas antibakteri Propionibacterium acnes dan formulasi ekstrak etanol biji pinang (Areca catechu, L) dalam krim anti jerawat (Antibacterial activity of Propionibacterium acnes and formulation of Areca catechu ethanolic extract in anti-acne cream)

Farid Salahudin, Heru Agus Cahyanto

Abstract


Abstrak. Telah dilakukan penelitian tentang ekstrak etanol biji pinang dalam aktivitasnya menghambat bakteri Propionibacterium acnes serta sebagai bahan aktif dalam formulasi krim anti jerawat. Ekstrak etanol biji pinang mengandung senyawa tanin dan flavonoid dengan kadar masing-masing 8,53 dan 3,70%. Hasil uji ekstrak etanol biji pinang dengan konsentrasi sebesar 1, 2 dan 3% memiliki  aktivitas daya hambat terhadap P. acnes sebesar 6,33 ; 9,33 dan 11,00 mm. Namun, sediaan krim ekstrak biji pinang dalam konsentrasi 2% belum mampu menghambat P. acnes. Dosis ekstrak biji pinang dalam sediaan krim yang mampu memberikan hambatan adalah 5, 10 dan 15% masing-masing sebesar 4, 5 dan 8 mm.

Kata kunci : ekstrak; jerawat; krim; pinang

 

Abstract. The research on Areca catechu ethanolic extract that inhibit Propionibacterium acnes and used as an active ingredient in anti acne cream formulation has been done. Ethanolic extract of areca contains tannin and flavonoid of 8.53 and 3.70%, respectively. Antibacterial test with concentrations of 1, 2 and 3% have an activity to P. acnes of 6.33; 9.33 and 11.00 mm. However, cream formulation with 2% concentration has not inhibit P. acnes yet. The dose in the cream formulation that is able to inhibit is 5, 10 and 15% respectively of 4, 5 and 8 mm.

Keywords : extract; acne; cream; areca

Keywords


extract; acne; cream; areca

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References


Banne, Y., & Suatan, R. (2012). Pembuatan salep anti jerawat dari ekstrak rimpang temulawak (Curcuma Xanthorrhiza Roxb.). Jurnal Ilmiah Farmasi Poltekkes Manado.

Biradar, S. V., Dhumal, R. S., & Paradkar, A. (2009). Rheological investigation of self-emulsification process: Effect of co-surfactant. Journal of Pharmacy and Pharmaceutical Sciences. https://doi.org/10.18433/j3qc7x

BPOM. (2019). Peraturan badan pengawas obat dan makanan Republik Indonesia. Badan Pengawas Obat Dan Makanan, 32, 1689–1699. https://doi.org/10.1017/CBO9781107415324.004

Cahyaningrum, G. R. (2014). Aktivitas antibakteri ekstrak etanol biji pinang (Areca catechu Linn) dan fraksinya terhadap pertumbuhan bakteri Propionibacterium acnes, Staphylococcus aureus, Dan Staphylococcus epidermidis. Universitas Muhammadiyah Purwokerto.

Dermawan, A. M., Pratiwi, L., & Kusharyanti, I. (2015). Efektifitas krim antijerawat ekstrak metanol daun pacar air (Impatiens balsamina L.). Majalah Obat Tradisional. https://doi.org/10.3390/s120810621

Desbois, A. P., & Lawlor, K. C. (2013). Antibacterial activity of long-chain polyunsaturated fatty acids against Propionibacterium acnes and Staphylococcus aureus. Marine Drugs, 11(11), 4544–4557. https://doi.org/10.3390/md11114544

Djajadisastra, J., Tranggono, R. I., & Latifah, F. (2007). Buku pegangan ilmu pengetahuan kosmetik. Jakarta: Gramedia, Hal, 11–13.

Eady, A. E., Cove, J. H., & Layton, A. M. (2003). Is antibiotic resistance in cutaneous propionibacteria clinically relevant?: Implications of resistance for acne patients and prescribers. In American Journal of Clinical Dermatology. https://doi.org/10.2165/00128071-200304120-00002

Faden, A. A. (2018). Evaluation of antibacterial activities of aqueous and methanolic extracts of areca catechu against some opportunistic oral bacteria. Biosciences Biotechnology Research Asia, 15(3), 655–659.

Jain, V., Garg, A., Parascandola, M., Chaturvedi, P., Khariwala, S. S., & Stepanov, I. (2017). Analysis of alkaloids in areca nut-containing products by liquid chromatography-tandem mass spectrometry. Journal of Agricultural and Food Chemistry, 65(9), 1977–1983. https://doi.org/10.1021/acs.jafc.6b05140

James, W., Elston, D., & Berger, T. (2011). Andrew’s Diseases of the Skin E-Book: Clinical Dermatology-Expert Consult-Online and Print.

Kemenkes. (2012). Registrasi obat tradisional. Peraturan Menteri Kesehatan Republik Indonesia.

Kemenkes. (2017). Formulasi ramuan obat tradisional Indonesia. 1–14.

Kementerian Kesehatan RI. (2015). Rencana Strategis Kementerian Kesehatan Republik Indonesia Tahun 2015-2019. Pusat Komunikasi Publik. https://doi.org/351.077 Ind r

M. Senthil Amudhan, V. H. B. and B. H. (2012). A review on phytochemical and pharmacological potential of areca catechu l. seed ,. 3(11), 4151–4157.

Malangngi, L., Sangi, M., & Paendong, J. (2012). Penentuan kandungan tanin dan uji aktivitas antioksidan ekstrak biji buah alpukat (Persea americana Mill.). Jurnal MIPA. https://doi.org/10.35799/jm.1.1.2012.423

Nakatsuji, T., Kao, M. C., Fang, J. Y., Zouboulis, C. C., Zhang, L., Gallo, R. L., & Huang, C. M. (2009). Antimicrobial property of lauric acid against propionibacterium acnes: Its therapeutic potential for inflammatory acne vulgaris. Journal of Investigative Dermatology, 129(10), 2480–2488. https://doi.org/10.1038/jid.2009.93

Pribadi, E. R. (2015). Pasokan dan permintaan tanaman obat indonesia serta arah penelitian dan pengembangannya. Perspektif, 8(1), 52–64. https://doi.org/10.21082/p.v8n1.2009.

Rita, W. S. (2010). Isolasi, identifikasi, dan uji aktivitas antibakteri senyawa golongan triterpenoid pada rimpang temu putih (Curcuma zedoaria (Berg) Roscoe). Jurnal Kimia.

Rowe, R. C., Sheskey, P., & Quinn, M. (2009). Handbook of pharmaceutical excipients. Libros Digitales-Pharmaceutical Press.

Sapara, T. U. (2016). Efektivitas antibakteri ekstrak daun pacar air (impatiens balsamina l.) terhadap pertumbuhan porphyromonas gingivalis. Pharmacon, 5(4).

Voight, R. (1994). Buku pengantar teknologi farmasi. Yogyakarta, Universitas Gadjah Mada Press.

Wang, C. K., & Lee, W. H. (1996). Separation, characteristics, and biological activities of phenolics in areca fruit. Journal of Agricultural and Food Chemistry. https://doi.org/10.1021/jf950611o

Xie, Y., Yang, W., Tang, F., Chen, X., & Ren, L. (2015). Antibacterial activities of flavonoids: structure-activity relationship and mechanism. Current Medicinal Chemistry, 22(1), 132–149.




DOI: http://dx.doi.org/10.24111/jrihh.v12i1.5424

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