Pengaruh Kecepatan Homegenisasi Terhadap Sifat Fisika dan Kimia Krim Nanopartikel dengan Metode High Speed Homogenization (HSH)

Galuh Suprobo, Dwina Rahmi

Abstract


Nanoparticle cream is the development of nanotechnology in cosmetics fields for improving the function of cream. High speed homogenization (HSH) is one of the methods for creating nanoparticle cream. In this research, the use of natural materials based palm oil derivative  such as stearic acid, cetil alcohol, cetil stearil alcohol was chosen in nanoparticle cream producing by using HSH methods.The speed variable of  homogenization of 1000 rpm, 1500 rpm, 2,000 rpm and 2,500 rpm  intended to find out the influence of speed toward the  properties of cream product. The observation result showed the influence on physical display in term of texture but not in homogeneity , stability and cream color. The pH of the product during two months storage for all variables were still stable. The particle size was increased in the homogeneity of speed at 2000 rpm and 2500 rpm. In this research has produced the cream in particle size from 239.86 to 358.10 nm which enter in nanoparticle category 50 nm to 1000 nm. The stability of nanoparticle cream product in the range of 97,20 to 98%.

ABSTRAK

Krim nanopartikel merupakan pengembangan nanoteknologi di bidang kosmetik untuk meningkatkan fungsi krim tersebut. High speed homogenization (HSH) merupakan salah satu metoda dalam pembuatan krim nanopartikel. Pada penelitian ini, krim nanopartikel dibuat menggunakan bahan baku alami turunan kelapa sawit yaitu asam stearat, setil alkohol, setil stearil alkohol dengan metoda HSH. Variabel kecepatan homogenisasi pada 1000 rpm, 1500 rpm, 2000 rpm dan 2500 rpm dimaksudkan untuk mengetahui pengaruh kecepatan terhadap sifat-sifat krim. Hasil menunjukkan bahwa perubahan kecepatan homogenisasi dalam reaktor berpengaruh terhadap tampilan fisik dari segi tekstur, akan tetapi tidak mempengaruhi terhadap kehomogenan, stabilitas dan warna krim. Dari pengamatan selama 2 bulan penyimpanan diketahui tidak terjadi perubahan pH selama penyimpanan untuk keempat variabel. Ukuran partikel semakin meningkat pada variabel homogenisasi 2000 rpm dan 2500 rpm. Ukuran partikel krim yang dihasilkan berkisar antara 239,86 – 358,10 nm yang termasuk kategori nanopartikel yang berkisar antara 50 nm sampai 1000 nm. Stabilitas emulsi dari krim nanopartikel yang dihasilkan berkisar antara 97,20 % sampai 98 %.


Keywords


Cream nanoparcle; cosmetic; high speed homogenizer; natural material; speed homogiztion

Full Text:

PDF

References


Agoes G. 2008. Pengembangan Sediaan Farmasi Edisi Revisi dan Perluasan. Bandung (ID): ITB.

Anief M. 2000. Ilmu Meracik Obat. Yogyakarta (ID): UGM Pr.

[Anonim]. 2007. Agitated Laboratory Reactors. Pressure Products Industries. [Internet]. [diunduh 2014 Sep 1]. Tersedia pada: http://www.gotoppi.com/Reactors.html.

Ansel HC. 2005. Pengantar Bentuk Sediaan Farmasi Ed ke-8. Jakarta (ID): UI Pr.

Anwar E. 2012. Eksipien dalam Sediaan Farmasi (Karakterisasi dan Aplikasi). Jakarta (ID): Dian Rakyat.

[ASTM] American Standar Testing Material. 2014. Committee E56 on Nanotechnology. Philadelphia (US): ASTM.

Awad T, Helgason T, Kristbergsson K, Decker EA, Weiss J, McClements DJ. 2008. Solid Lipid Nanoparticles as delivery systems for bioactive food components. Food Biophysics. 3:146–154

Balsam MS, SD Gerson, MM Rieger, E Sagarin, Sj Strianse. 1972. Cosmetics: Science amd Technology. New York (US): J Wiley.

Carter JS. 1975. Dispensing for Pharmautical Student 12th ed. London (UK): Pitman Medical.

Dahayanake M, Rosen MJ. 2000. Industrial Utilization of Surfactants: Princples and Practice. Urbana (US): AOCS Pr.

[Depkes RI]. Departemen Kesehatan Republik Indonesia. 1976. Peraturan Menteri Kesehatan RI no.220/MenKes/Per/IX/76 tentang Produksi dan Peredaran Kosmetika dan Alat Kesehatan Menteri Kesehatan Republik Indonesia. Jakarta (ID): Depkes RI.

Hambali E, Suryani A, Sailah I. 2000. Teknologi Emulsi. Bogor (ID): IPB.

Iswari R & Latifah F.2007. Buku Pegangan Ilmu Pengetahuan Kosmetik. Jakarta(ID): Gramedia Pustaka Utama.

Kodeks Kosmetika Indonesia Ed ke-1.1993. Volume 3.

Lachman L, Lieberman HA, Kanig JL. 2008. Teori dan Praktek Farmasi Industri II Ed ke-3. Jakarta (ID): Universitas Indonesia Pr.

Lidiyah. 2011. Peningkatan jumlah nanopartikel kitosan terisi ketoprofen berdasarkan ragam surfaktan dan kondisi ultrasonikasi [skripsi]. Bogor (ID): Sekolah Pascasarjana. Institut Pertanian Bogor.

McClements DJ. 2004. Food Emulsion Principle, Practices, and Techniques. New York(US): CRC Pr.

Medha DJ, Wedny JU, Gert S, Yvette Vk, Enrico M. 2012. Journal of Controlled Release. 161(4): 25-37.

Menhnert W, Mader K. 2001. Advanced drug delivery. 47: 165-196

Müller-Fischer N, Suppiger D, Windhab EJ. 2006. Impact of static pressure and volmetric energy input on the microstructure of food foam whipped in a rotor-stator device. J. Food Engineering. 80 : 306-316.

Müller Rh, hommoss A, Pardeike J, Schmidt C. 2007. Lipid nanoparticles (NLC) as novel carrier for cosmetic-spesial feature & state of commercialisation. SÖFW-J. 40-46.

Musthaba MS, Sanjula B, Sayeed A, Alka A, Javed A. 2009. Status of Novel Drug Delivery Technology for Phytotherapeutics. India (IN) : Hamdard University.

Nagarajan R. 2008. Nanoparticles: Building Blocks of Nanotechnology. Di dalam: Nagarajan R & Hatton TA, editor. Nanoparticles: Synthesis, Stabilization, Passivation, and Functionalization. Proceedings of the Symposium at the 233rd Meeting on the American Chemical Society; Chicago, 25–29 Maret 2007. Washington: American Chemical Society. hlm. 2–15.

Pang X, Cui F, Tian J, Chen J, Zhou J, Zhou W. 2009. Preparation and characterization of magnetic solid lipid nanoparticles Loaded with ibuprofen. Asian Journal of Pharmaceutical Science 4:132–137.

Pardeike J, Hommonss A, Müller RH. 2009. Lipid nanoparticles (SLN, NLC) in cosmetics and pharmaceutical dermal products. International Journal of Pharmaceutics. 170-184.

Rahmi D, Yunilawati R, Ratnawati E. 2013. Peningkatan stabilitas emulsi krim nanopartikel untuk mempertahankan kelembaban kulit. J. Kimia dan Kemasan. 35(1): 30-36.

Rawie A. 2010. Technical Paper: Basic Principles of Particle Size Analysis. Worcestershire (GB): Malvern Instruments Limited.

Rowe RC, Sheskey PJ, Quinn ME. 2009. Handbook of Pharmaceutical Excipients. London (UK): Pharmaceutical Press and American Pharmaceutical Association.

[SNI] Standar Nasional Indonesia. 2005. Sediaan Tabir Surya. SNI 16-4399-1996. Jakarta (ID): Badan Standardisasi Nasional.

Suryani A, Sailah I, Hambali E. 2000. Teknologi Emulsi. Bogor (ID): IPB.

Thassu D, Pathak Y, Deleers M. 2007. Nanoparticulate Drug-Delivery System. New York (US): Informa.

Yen FL, Wu TH, Lin LT, Cham TM, Lin CC. 2008. Nanoparticles formulation of Cucuta chijnensis prevents acetaminophen-induced hepatotoxicity in rats. Food and Chemical Toxicology. 46: 1771–1777.




DOI: http://dx.doi.org/10.24960/jli.v5i1.661.1-12

Refbacks

  • There are currently no refbacks.




Copyright (c) 2015 Galuh Suprobo, Dwina Rahmi


Our journal indexed by:




Copyright © Baristand Industri Padang, 2015. Powered By OJS

Theme design credited to MEV edited by JLI

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License