Influence Of Drying Time And Temperature On Zirconium-Based Material (ZBM) Properties For 99Mo/99mTc Generator Development

Miftakul Munir, Endang Sarmini, Herlina Herlina, Anung Pujiyanto, Indra Saptiama, Kadarisman Kadarisman, Shella Kurnia


Zirconium-based material (ZBM) has an important role in producing Technetium-99m (99mTc) due to its high adsorption capacity to Molybdenum-99 (99Mo). The adsorption capacity of the ZBM depends on the specific surface area which is influenced by several parameters in the synthesis process. This study aims to investigate the influence of drying time and temperature on the structure and specific surface area of the ZBM. Synthesis of the ZBM was carried out using zirconium chloride, 2-propanol, water and tetrahydrofuran at 75 °C, 90 °C and 120 °C and for 3 hr, 5 hr and 7 hr, respectively. Functional group and specific surface area of the ZBM was analyzed by FTIR and BET method, respectively. At the variation of drying time, the functional group pattern showed by FTIR spectra was not significantly different. The O-H group of the ZBM increased as the drying temperature decreases. At 75 and 90°C, the specific surface area increased as the function of time was increased but was decreased at 120°C. The highest surface area of the synthesized ZBM had a poor performance as a 99Mo/99mTc generator material, whereas the eluate met the required standard.


ZBM, Sol-gel, Time, Temperature, Drying

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Amin, M, M Mostafa, M. A. El-Amir, O I Mohamed, A B Farag, and M. A. El-Absy. 2014. “99Mo /99m Tc Generator Based on High Radionuclidic Pure Zirconium Molybdate Gel.” Arab Journal of Nuclear Science and Applications 47 (2): 15–25.

Awaludin, Rohadi, AdangHardi Gunawan, Hotman Lubis, Sriyono, Herlina, Abdul Mutalib, Akihiro Kimura, Kunihiko Tsuchiya, Masakazu Tanase, and Masahiro Ishihara. 2015. “Mechanism of 99Mo Adsorption and 99mTc Elution from Zirconium-Based Material in 99Mo/ 99mTc Generator Column Using Neutron-Irradiated Natural Molybdenum.” Journal of Radioanalytical and Nuclear Chemistry 303 (2): 1481–83.

Blaauw, M., D. Ridikas, S. Baytelesov, P. S. Bedregal Salas, Y. Chakrova, Cho Eun-Ha, R. Dahalan, et al. 2017. “Estimation of 99Mo Production Rates from Natural Molybdenum in Research Reactors.” Journal of Radioanalytical and Nuclear Chemistry 311 (1): 409–18.

Cutler, Cathy S, and Sally W Schwarz. 2014. “Diversification in the Supply Chain of 99Mo Ensures a Future for 99mTc.” Journal of Nuclear Medicine 55 (7): 1208–13.

Danks, A. E., S. R. Hall, and Z. Schnepp. 2016. “The Evolution of ‘sol–gel’ Chemistry as a Technique for Materials Synthesis.” Mater. Horiz. 3 (2). Royal Society of Chemistry: 91–112.

Dash, Ashutosh, F.F. (Russ) Knapp, and M.R.A. Pillai. 2013. “99Mo/99mTc Separation: An Assessment of Technology Options.” Nuclear Medicine and Biology 40 (2). Elsevier Inc.: 167–76.

Iswar, Subramaniam, Wim J. Malfait, Sandor Balog, Frank Winnefeld, Marco Lattuada, and Matthias M. Koebel. 2017. “Effect of Aging on Silica Aerogel Properties.” Microporous and Mesoporous Materials 241 (March). Elsevier Ltd: 293–302.

Le, Van So. 2014. “99m Tc Generator Development: Up-to-Date 99m Tc-Recovery Technologies for Increasing the Effectiveness of 99 Mo Utilization.” Sci Technol Nuclear Installations 2014: 1–41.

Mahesh, Mahadevappa, and Mark Madsen. 2017. “Addressing Technetium-99m Shortage.” Journal of the American College of Radiology 14 (5). American College of Radiology: 681–83.

Marlina, E Sarmini, Herlina, Sriyono, I Saptiama, H Setiawan, and Kadarisman. 2017. “Preparation and Characterization of Zirconia Nanomaterial as a Molybdenum-99 Adsorbent.” Atom Indonesia 43 (1): 1–6.

Marlina, Sriyono, Enny Lestari, Abidin, Herlan Setiawan, and Kadarisman. 2016. “Desain Dan Performa Prototipe Generator 99Mo/99mTc Dengan Kolom Material Berbasis Zirkonium Dan Kolom Alumina.” J Kimia Dan Kemasan 38 (2): 93–102.

Munir, Miftakul, Enny Lestari, Endang Sarmini, Herlina, Sriyono, and Marlina. 2017. “Pengaruh Radioaktivitas 99Mo Terhadap Profil Rendemen 99mTc Pada Generator 99Mo/99mTc Dengan Kolom Material Berbasis Zirkonium (MBZ).” Ganendra 20 (1): 1–7.

Omranpour, Hosseinali, and Siamak Motahari. 2013. “Effects of Processing Conditions on Silica Aerogel during Aging: Role of Solvent, Time and Temperature.” Journal of Non-Crystalline Solids 379. Elsevier B.V.: 7–11.

Pillai, M. R. A., A. Dash, and F. F. Knapp. 2013. “Sustained Availability of 99mTc: Possible Paths Forward.” Journal of Nuclear Medicine 54 (2): 313–23.

Pillai, Maroor R a, Ashutosh Dash, and F. F. Knapp. 2015. “Diversification of 99Mo/99mTc Separation: Non-Fission Reactor Production of 99Mo as a Strategy for Enhancing 99mTc Availability.” Journal of Nuclear Medicine 56 (1): 159–61.

Saha, Gopal B. 2018. Fundamentals of Nuclear Pharmacy. 7thed. Cham: Springer Nature.

Saptiama, I, E Lestari, E Sarmini, H Lubis, Marlina, and A Mutalib. 2016. “Development of 99 Mo/99m Tc Generator System for Production of Medical Radionuclide 99m Tc Using a Material (ZBM) as Its Adsorbent.” Atom Indonesia 42 (3): 115–21.

Saptiama, I, Marlina, E Sarmini, Herlina, Sriyono, Abidin, H Setiawan, Kadarisman, H Lubis, and A Mutalib. 2015a. “The Use of Sodium Hypochlorite Solution for (N, Y) 99 Mo / 99m Tc Generator Based on Zirconium-Based Material (ZBM).” Atom Indonesia 41 (2): 103–9.

———. 2015b. “The Use of Sodium Hypochlorite Solution for (N, Y) 99Mo/99mTc Generator Based on Zirconium-Based Material (ZBM).” Atom Indonesia 41 (2): 103–9.

Saptiama, Indra, Herlina, Endang Sarmini, Sriyono, Hotman Lubis, Herlan Setiawan, Marlina, and Abdul Mutalib. 2014. “Optimasi Penyerapan Molybdenum-99 Pada Material Berbasis Zirkonium (MBZ).” In Prosiding Seminar Nasional Sains Dan Pendidikan Sains IX, 615–20. Salatiga: UKSW.

Selivanova, Svetlana V, Éric Lavallée, Helena Senta, Lyne Caouette, Alexander J B Mcewan, Brigitte Guérin, Roger Lecomte, and Éric Turcotte. 2016. “Clinical Trial Using Sodium Pertechnetate 99m Tc Produced with Medium-Energy Cyclotron: Biodistribution and Safety Assessment in Patients with Abnormal Thyroid Function.” J NucI Med of Nuclear Medicine 58: 791–99.

Seraji, Mohamad Mehdi, Ghasem Sameri, Jamal Davarpanah, and Ahmad Reza Bahramian. 2017. “The Effect of High Temperature Sol-Gel Polymerization Parameters on the Microstructure and Properties of Hydrophobic Phenol-Formaldehyde/silica Hybrid Aerogels.” Journal of Colloid and Interface Science 493 (May). Elsevier Inc.: 103–10.

Seraji, Mohamad Mehdi, Azadeh Seifi, and Ahmad Reza Bahramian. 2015. “Morphology and Properties of Silica/novolac Hybrid Xerogels Synthesized Using Sol-Gel Polymerization at Solvent Vapor-Saturated Atmosphere.” Materials and Design 69. Elsevier Ltd: 190–96.

So, Le Van, Nguyen Cong Duc, Bui Van Cuong, and Vo Cam Hoa. 2007. “Synthesis, Characterization and Application of Zirconium and Titanium Inorganic Polymer Sorbents for The Preparation of Chromatographic 99mTc and 188Re Generators.” In Development of Generator Technologies for Therapeutic Radionuclide, 1–20.

Soleimani Dorcheh, A., and M. H. Abbasi. 2008. “Silica Aerogel; Synthesis, Properties and Characterization.” Journal of Materials Processing Technology 199 (1): 10–26.

United State Pharmacopeia/National Formulary. 2011. USP 35/NF. Maryland: United States Pharmacopeial Convention.

Zhao, Junlong, Hao Xu, Dazhen Tang, Jonathan P. Mathews, Song Li, and Shu Tao. 2016. “A Comparative Evaluation of Coal Specific Surface Area by CO2 and N2 Adsorption and Its Influence on CH4 Adsorption Capacity at Different Pore Sizes.” Fuel 183 (November). Elsevier Ltd: 420–31.

Zolle, Ilse. 2007. “Performance and Quality Control of the 99Mo/99mTc Generator.” In Technetium-99m Pharmaceuticals: Preparation and Quality Control in Nuclear Medicine, edited by Ilse Zolle, 86–90. Vienna.



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