Imobilisasi Propanolol HCl Pada Hidrogel Poli(Vinil Alkohol) - Natrium Alginat Dengan Teknik Radiasi

Erizal Erizal, Erlina Widianti Pratiwi, Dian Pribadi Perkasa, Noviyantih Noviyantih, Basril Abbas, Sudirman Sudirman

Abstract


Penelitian ini bertujuan memanfaatkan hidrogel sebagai matriks imobilisasi obat dengan teknik iradiasi gamma untuk mengontrol laju pelepasan obat terkendali. Imobilisasi propanolol HCl dalam hidrogel poli(vinil alkohol) (PVA)-g-natrium alginat (NaAlg) telah dilakukan. Larutan PVA/NaAlg (5/0,5, %berat)  yang mengandung  propanolol HCl (8 mg sampai dengan 16 mg), dibeku-lelehkan (3 siklus) dan diradiasi dengan variasi  dosis (10 kGy sampai dengan 30 kGy). Hidrogel dikarakterisasi dengan spectrophotometer Fourier Transform-Infra Red (FT-IR) dan Scanning Electron Microscope (SEM). Fraksi gel dan daya serap air ditentukan secara gravimetri. Uji pelepasan propanolol HCl dari hidrogel dilakukan dalam larutan encer  fosfat (pH 6,8) pada suhu 37 °C diukur dengan spectrofotomer Ultraviolet Visible (UV-Vis). Hasil evaluasi menunjukkan peningkatan dosis iradiasi dari 10 kGy hingga 30 kGy, peningkatan fraksi gel hidrogel, dan kemampuan menyerap air hidrogel relatif turun. Pelepasan kumulatif obat dari matriks hidrogel dengan meningkatnya dosis iradiasi hingga 30 kGy relatif turun. Pengamatan menggunakan SEM, menunjukkan hidrogel PVA-NaAlg mempunyai struktur pori yang tidak teratur. Hidrogel PVA-g-NaAlg selayaknya dapat digunakan sebagai matriks pelepasan obat. 


Keywords


Imobilisasi, Hidrogel, Poli(vinil alkohol), Propanolol HCL , Natrium alginat

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References


Catelas, I., J. F. Dwyer, and S. A. M. Helgerson. 2008. “Controlled Release of Bioactive Transforming Growth Factor Beta-1 from Fibrin Gels in Vitro.” Tissue Engineering 14 (2). doi:10.1089/ten.tec.2007.0262.

Chowdhury, M. A. 2014. “International Journal of Biological Macromolecules The Controlled Release of Bioactive Compounds from Lignin and Lignin-Based Biopolymer Matrices.” International Journal of Biological Macromolecules 65: 136-147. doi:10.1016/j.ijbiomac.2014.01.012.

Defail, A. J., H. D. Edington, S. Matthews, W. C. Lee, and K. G. Marra. 2006. “Controlled Release of Bioactive Doxorubicin from Microspheres Embedded within Gelatin Scaffolds.” Journal of Biomedical Materials Research 79A(4):2–4. doi:10.1002/jbm.a.

Dutta, J. 2012. “Synthesis and Characterization of γ -Irradiated PVA/PEG/CaCl2 Hydrogel for Wound Dressing.” American Journal of Chemistry 2 (2): 6–11. doi:10.5923/j.chemistry.20120202.02.

El-mohdy, H. L. A. 2013. “Radiation Synthesis of Nanosilver/Poly Vinyl Alcohol/Cellulose Acetate/Gelatin Hydrogels for Wound Dressing.” Journal of Polymer Research 20(6). doi:10.1007/s10965-013-0177-6.

Elliott, I., and M. S. Shoichet. 2015. “Acta Biomaterialia Controlled Release of Bioactive PDGF-AA from A Hydrogel/Nanoparticle Composite.” Acta Biomaterialia 25:35-42. doi:10.1016/j.actbio.2015.08.002.

Erizal, E., and Z. Abidin. 2011. “Sintesis Hidrogel Campuran Poli (Vinil Alkohol) (PVA)-Natrium Alginat Dengan Kombinasi Beku-Leleh Dan Radiasi Gamma Untuk Bahan Pembalut Luka Synthesis Of Hydrogel Poly (Vinyl Alcohol) (PVA)-Sodium Alginate Blend by Freeze-Thawing Followed by Ga.” Jurnal Ilmiah Aplikasi Isotop Dan Radiasi 7: 21–28.

Guo, L., H. Zhang, D. Fortin, H. Xia, and Y. Zhao. 2015. “Poly (Vinyl Alcohol)-Poly (Ethylene Glycol) Double-Network Hydrogel : A General Approach to Shape Memory and Self-Healing Functionalities Poly (Vinyl Alcohol)-Poly (Ethylene Glycol) Double-Network Hydrogel : A General Approach to Shape Memory an.” Langmuir 31(42): 11709-11716. doi:10.1021/acs.langmuir.5b03474.

Hoare, T. R., and D. S. Kohane. 2008. “Hydrogels in Drug Delivery : Progress and Challenges *.” Polymer 49 (8): 1993-2007. doi:10.1016/j.polymer.2008.01.027.

Hudson, S. P., R. Langer, G. R. Fink, and D. S. Kohane. 2010. “Biomaterials Injectable in Situ Cross-Linking Hydrogels for Local Antifungal Therapy.” Biomaterials 31 (6): 1444–1452. doi:10.1016/j.biomaterials.2009.11.016.

Kalhapure, A., and U. Pradesh. 2016. “Hydrogels : A Boon for Increasing Agricultural Productivity in Water-Stressed Environment.” Current Science 111 (11): 1773–1779. doi:10.18520/cs/v111/i11/1773-1779.

Kamoun, E. A., X. Chen, M. S. Mohy, and E. S. Kenawy. 2015. “Crosslinked Poly (Vinyl Alcohol) Hydrogels for Wound Dressing Applications : A Review of Remarkably Blended Polymers.” Arabian Journal of Chemistry 8 (1): 1–14. doi:10.1016/j.arabjc.2014.07.005.

Lee, M., H. Bae, S. Lee, N. Chung, H. Lee, S. Choi, S. Hwang, and J. Lee. 2011. “Freezing/Thawing Processing of PVA in the Preparation of Structured Microspheres for Protein Drug Delivery.” Macromolecular Research 19 (2): 130-136. doi:10.1007/s13233-011-0203-7.

Lin, C., and A. T. Metters. 2006. “Hydrogels in Controlled Release Formulations : Network Design and Mathematical Modeling ☆.” Adv Drug Deliv Rev. 58 (12-13):1379-1408. doi:10.1016/j.addr.2006.09.004.

Lin, S., and L. Gu. 2015. “Influence of Crosslink Density and Stiffness on Mechanical Properties of Type I Collagen Gel.” Materials (Basel). 8 (2): 551-560. doi:10.3390/ma8020551.

Masuelli, M. A., and C. O. Illanes. 2014. “Review of the Characterization of Sodium Alginate by Intrinsic Viscosity Measurements.Comparative Analysis between Conventional and Single Point Methods.” International Journal of BioMaterials Science and Engineering 1 (1): 1-11.

Rizi, K., R .J. Green, O. Khutoryanskaya, M. Donaldson, and A. C. Williams. 2011. “Mechanisms of Burst Release from pH-Responsive Polymeric Microparticles.” J Pharm Pharmacol.63(9):1145-1155.

Sylman, J. L., and K. B. Neeves. 2013. “An Inquiry-Based Investigation of Controlled-Release Drug Delivery from Hydrogels: An Experiment for High School Chemistry and Biology.” J. Chem. Educ 90 (7): 918-921.

Wong, R. S. H., M. Ashton, and K. Dodou. 2016. “Analysis of Residual Crosslinking Agent Content in UV Cross-Linked Poly (Ethylene Oxide) Hydrogels for Dermatological Application by Gas Chromatography." Journal of Pharmaceutical Analysis 6(2016) : 307-312.




DOI: http://dx.doi.org/10.24817/jkk.v40i1.2755

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